Its chronic course with deteriorating consequences has been the focus of fundamental kraepelinian theory of “ dementia praecox ” to biological correlates and explanation 本论文回顾精神分裂病观念之改变,从传统克贝林所提供之早发性痴呆理论至目前分子生物医学的研究发现与假说。
Dementia praecox (a "premature dementia" or "precocious madness") refers to a chronic, deteriorating psychotic disorder characterized by rapid cognitive disintegration, usually beginning in the late teens or early adulthood. It is a term first used in 1891 in this Latin form by Arnold Pick (1851?1924), a professor of psychiatry at the German branch of Charles University in Prague.